CXCR3 and neoplasm: Altogether, it is reasonable to assume that the following process occurs after T-BsAb administration: (i) the T-BsAb is first delivered to the tumor tissue, where it crosslinks a tumor cell and a preexisting T cell; (ii) crosslinking induces T cell activation and causes the tumor to develop the inflamed phenotype, exemplified by active secretion of cytokines and chemokines; and (iii) peripheral T cells that express CXCR3 are recruited toward the tumor tissue according to the concentration gradient of pro-migration factors