It is thus no surprise that neurological syndromes and disorders such as DS [14,34,43,44,45,46,47,48,49,50,51,52,53,54], Alzheimer’s disease [44], Parkinson’s [55,56,57], and Pick’s disease [58] all involve abnormal expression of DYRK1A [59]. Here, DYRK1A is linked to early-onset autosomal dominant Alzheimer disease.