We revealed changes dependent on the hypertension model, since both KCNN4 and KCNN3 were downregulated in the aortas and mesenteric G3 arteries of SHR, whereas their expression levels were unchanged in DOCA-salt rats, with the exception of the KCNN4 level being enhanced in aortas. The gene discussed is KCNN4; the disease is Hypertension.