The mechanism by which CBD improves endothelial function in hypertension depends on the vessel diameter and may be partly associated with its NO-; KCa3.1-; or NO, COX(PGI2) and EDH (KCa3.1 and KCa2.3)-dependent effect on aortas and mesenteric G3 arteries, respectively. The gene discussed is KCNN3; the disease is Hypertension.