REN and hypertensive disorder: We used two hypertension models with different etiologies, but both were associated with vascular target-organ damage, including vascular dysfunction and remodeling [9,32]: (1) genetic SHR resembling the hypertensive phenotypes of human hypertension, used for the screening of antihypertensive agents [32]; (2) DOCA-salt-induced hypertension with some features of human low-renin hypertension.