Trimethoxyphenyl-1,2,3-triazole hybrids, such as 4b, containing the coumarin fragment, inhibit human gastric MGC803 cancer cell growth, induce G2/M phase arrest by down-regulating the expression of CDK1, promote apoptosis by regulating Death Receptor 5 (DR5) and the Bcl-2 family of proteins and inhibit tubulin polymerisation by interacting with the colchicine site [23]. This evidence concerns the gene TNFRSF10B and cancer.