As a matter of fact, in several studies apple peel extract (APE) and apple pulp extract (APP) have shown anti-inflammatory and anti-oxidative stress effects in animal models of renal ischemia/reperfusion injury, carbon tetrachloride (CCl4)-induced hepatotoxicity, diabetic pancreas model and colitis via down regulation of NF-kB, pro-inflammatory cytokines, increasing the antioxidant enzyme activity including superoxide dismutase (SOD), catalase (CAT) and reducing myeloperoxidase (MPO) activity [1,17,18,19]. The gene discussed is MPO; the disease is colitis.