Moreover, a comparison of the kinetics of cytokine production [100] and PD-L1 expression [99] in hepatocellular carcinoma cell culture supernatant (TSN)-treated monocytes revealed that the accumulation of TNF-α and IL-10 preceded the upregulation of PD-L1, suggesting a novel immune-editing mechanism by which tumors increased the suppressor activity of activated monocytes by stimulating IL-10 and PD-L1 expression [99]. The gene discussed is CD274; the disease is hepatocellular carcinoma.