CD274 and viral infectious disease: Brooks et al. demonstrated that in mice, IL-10 and PD-L1 suppress antiviral T cell activity via separate pathways and consequently, simultaneous blockade of IL-10 and PD-L1 dramatically increases T cell responses over that seen by neutralizing either molecule alone, and the combinatorial blockade of both IL-10 and PD-L1 rapidly eliminates persistent virus infection [107].