Others showed that a high expression of IL-10 in tumor-associated macrophages (TAMs) is correlated with an adverse prognosis and a more advanced tumor stage, but no significant difference has been seen between IL-10 expression in tumor cells and stage [53].The same results, suggesting a worse prognosis in patients with pancreatic cancer and high levels of IL-10, are presented by Feng et al. in their retrospective study [54]. This evidence concerns the gene IL10 and familial pancreatic carcinoma.