This is an anti-TNF-α monoclonal antibody approved by Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, plaque psoriasis, and hidradenitis suppurativa [13]. This evidence concerns the gene TNF and rheumatoid arthritis.