Although SFN can significantly engage the antioxidant activity of nuclear factor erythroid 2-related factor 2 (NRF2) [28,29] and protect normal cells to toxic agents and therapies such as radiations, several lines of experimental evidence have demonstrated that SFN shows cytotoxic and pro-apoptotic effects in different cancer cell types including glioma cells [23,24,25,26,27,28,29]. This evidence concerns the gene NFE2L2 and cancer.