The qRT-PCR analysis showed that EGCG downregulated PD-L1 and PD-L2 genes in 1205Lu and HS294T cells and reversed the IFN-γ-induced upregulation of PD-L1 and PD-L2 genes in all three melanoma cell lines (Figure 1C). This evidence concerns the gene PDCD1LG2 and melanoma.