HLA-B and gout: A recent guideline released from the American College of Rheumatology (ACR) for the management of gout has recommended conditional HLA-B*58:01 allele testing before starting allopurinol therapy for the patients of Southeast Asian descent (e.g., Han Chinese, Korean, Thai) and African American due to having higher prevalence of HLA-B*58:01 allele in these ethnic groups although the certainty of evidence for this recommendation was very low [141].