In the univariate Cox analysis, increased serum SOD1 concentration per 1 pg/mL, increased serum SOD2 concentration per 1 ng/mL, increased albumin concentration per 1 g/dL, CRP > 10 mg/dL, GPS > zero, serum ceruloplasmin concentration above the median value, clinical stages III and IV, presence of DM, platelets >400 × 103 cells/μL, NLR above the median value, increased alkaline phosphatase activity per 1 U/L, and increased glucose per 1 mg/dL were all significant predictors of overall mortality in lung cancer patients. Here, SOD2 is linked to lung cancer.