PDCD6IP and neoplasm: The HIV-1 “late domain” p6 subunit contains two conserved motifs, PTAP and YPXnL (where Xn represents one to three variable residues), which bind to two members of the ESCRT family, TSG101 (Tumor Susceptibility Gene 101) and Alix (ALG-2 Interacting Protein X), respectively [66].