Of these cases, only three were extended beta-lactamase producer isolates and considered as extended-spectrum beta-lactamase Enterobacteriaceae; one encoded SHV-type beta-lactamases in a 58-year-old man with acute myeloid leukemia [23], the second harbored bla (TEM-1) and bla (CTX-M) group 1 and intl1 genes (dfrA12-orfF-aadA2) as genetic determinants for resistance in a 47-year-old female with breast cancer and catheter-related bacteremia [18] and the third was ESBL-producing a multidrug-resistant L. adecarboxylata strain in a 50-year-old female with end-stage renal disease [10]. This evidence concerns the gene LACTB and breast cancer.