LDLR and atherosclerosis: In line, genetic model rodents survive with an inactivation of the LDL receptor-mediated cholesterol uptake pathway by harboring a mutation in the LDL-receptor gene or the ApoE gene, which codes for the major apolipoprotein in mice and other genes associated with the LDL-receptor family, such as VLDLR or ApoE4 receptor without severe atherosclerosis [67].