DIRAS3 and neoplasm: In an ovarian cancer model, the reexpression of DIRAS3 (also known as ARHI, a tumor suppressor that is commonly downregulated in breast and ovarian malignancies [101,102]), although inducing significant cell death, was shown to inhibit mTOR and its downstream effector p70S6K, plus activating autophagy, which cause a subpopulation of cells to enter a dormant state [102].