HSD11B1 and osteosarcoma: It is possible that the DHT and E2 protective action observed in 7-day-differentiated osteoblasts and osteocytes exposed to dexamethasone could be related to the induction of HSD11b1 gene expression caused by dexamethasone, as was found by Kaur in primary human osteoblasts and MG-63 osteosarcoma cells [49].