Secondly, this study is the first in vitro investigation to evaluate the potential role of TRPM7 in NK cell cytotoxicity and the co-localization of TRPM7 with PIP2 after IL-2 stimulation and pharmacological treatment with NTB or NS8593 in the NK cells of both ME/CFS patients and healthy controls (HCs). This evidence concerns the gene TRPM7 and myalgic encephalomeyelitis/chronic fatigue syndrome.