Interestingly, NEDD4 (i) is overexpressed in the brain regions presenting Lewy pathology and a single nucleotide polymorphism in its coding sequence is associated with a greater risk of PD onset [17]; (ii) is protective against human aS toxicity in evolutionary distant models [18]; (iii) a small molecule able to activate NEDD4 functions, has an effect on aS toxicity [19]. Here, NEDD4 is linked to Parkinson disease.