This is interesting, as the role of GSK3 in pathology is often found associated with that of the innate immune/antiviral/stress response kinase PKR, which is both an inducer of type I IFNs as well as an IFN response gene known to be involved in neurodegenerative diseases (Alzheimer’s disease, Huntington’s chorea and Creutzfeldt–Jakob disease), muscular degenerative disease (myotonic dystrophy) and cachexia [94]. The gene discussed is EIF2AK2; the disease is early-onset autosomal dominant Alzheimer disease.