CD8A and neoplasm: Xu et al. showed that the Renca cell-derived exosome (RDE) stimulated CD8+ T cells to produce specific cytotoxicity affecting autologous tumor cells through the Fas ligand (FasL)/Fas signaling pathway, and the combination of CD8+ T cells stimulated by RDE with GM-CSF and IL-12 enhanced the anti-tumor effect [22].