Interestingly, the genetic interaction between MMP9 and FMRP also occurs in nonneuronal tissues, which might explain the nonneuronal symptoms of FRAXA patients, such as JHM, the hallmark characterizing hEDS, and some orthopedic features (e.g., flat foot and scoliosis). The gene discussed is FMR1; the disease is Ehlers-Danlos syndrome, hypermobility type.