FN1 and Ehlers-Danlos syndrome, hypermobility type: Together, these findings corroborate the hypothesis that MMPs-mediated FN-ECM disorganization, activating an αvβ3 integrin-mediated signaling, is likely an important, but not the only, trigger underlying the hEDS pathogenesis, considering the incomplete myofibroblast dedifferentiation of hEDS cells in the presence of doxy.