Response to anti-PD-1 treatment has been associated with loss of function mutations in PBRM1, a member of the SWI/SNF chromatin remodeling complex and one of the most commonly altered ccRCC genes seen in up to 50% of cases [135], resulting in aberrant expression of immune-related, JAK/STAT, and hypoxia pathways [136,137]. Here, PBRM1 is linked to nonpapillary renal cell carcinoma.