Among the three ccRCC subtypes, high expression of the genes for PD-1, CTLA-4, and TLR9 were associated with decreased survival, while PD-L1 was linked with better outcomes (though per authors this may be confounded by the loss of 9p, which contains the PD-L1 locus, leading to more aggressive disease) [5]. The gene discussed is CD274; the disease is nonpapillary renal cell carcinoma.