Finally, tumor stratification based on DNA repair gene expression identified high-risk tumors with increased expression of the checkpoints PD-1, LAG-3, CTLA-4, TIGIT [83], and classifying tumors by high expression of the immune checkpoints PD-1, PD-L1, PD-L2, and LAG-3, as well as the absence of mature DCs, was associated with poor prognosis even in the setting of CD8 T cell infiltration [121]. This evidence concerns the gene CD8A and neoplasm.