In one study quantitating immune cytolytic activity based on the expression level of the CD8 T cell cytolytic effector molecules granzyme A (GZMA) and perforin (PRF1), ccRCC ranked highest among 15 cancer types, and the scoring was markedly increased compared to pRCC and benign renal tissue [40]. The gene discussed is CD8A; the disease is nonpapillary renal cell carcinoma.