Finally, multiple immune checkpoints, including PD-L1, PD-1, CTLA-4, LAG-3, TIM-3, and TIGIT, have been associated with genomic instability [113], long non-coding RNAs [114], TNFRSF9 expression and TNFRSF9+ CD8 TILs [115], and CXCL13+ CD8 TILs [116] in RCC. Here, CD274 is linked to renal cell carcinoma.