CD8A and neoplasm: Among the T cell subsets, Th1 T cells, Th17 T cells, and high Th17/Treg and CD8/Treg ratios have been associated with improved survival [32,34,37], while Tregs (circulating, tumor infiltrating, and specifically ICOS+ Tregs) and Th2 T cells were associated with decreased survival [32,34,43,121,127].