When analyzing the soluble form of immune checkpoints in the periphery of ccRCC patients, correlations were observed between soluble BTLA and TIM-3 and decreased survival, PD-L2 with recurrence, TIM-3 and LAG-3 with advanced stage, and LAG-3 and CD28 negatively correlated with T cell cytolytic activity [123]. Here, HAVCR2 is linked to nonpapillary renal cell carcinoma.