IL6 and obesity due to melanocortin 4 receptor deficiency: Our results show that there is a cooperative interaction between IL-1β and TNFα that requires CREB binding and H3K14 acetylation, and leads to the activation of IL-6 expression in adipocytes, providing interesting pathophysiological network among IL-1β, TNFα, and IL-6 in metabolic inflammatory settings such as obesity.