IGHE and Cowden syndrome 1: The importance of IDT in the treatment of allergic disease: Many clinical studies over the past 75 years have shown that manifestations of allergy (rhinitis, chronic sinusitis (CS), asthma, eustachian tube dysfunction (ETD), and eczema) are associated with positive in vivo or in vitro tests for IgE-mediated hypersensitivity [1,2].