PTEN and neoplasm: LTB4 is a proinflammatory mediator that is produced by myeloid cells in mammals [27] in response to an inflammatory insult, and we recently demonstrated its role in tumor-related inflammation in Drosophila Notch-Pten tumors [4], where active lipid proinflammatory mediators are also produced by the tumor cells in Pten-deficient cells.