YAP1 and neoplasm: Consistent with those findings, the group of Nobert Perrimon [87] showed that ImpL2 is a cachexic mediator in a different fly tumor model overexpressing yorkie (yki) in the adult midgut, which leads to wasting of the ovary, fat body, and muscle associated with systemic insulin resistance [87], a feature also reported in human patients and mouse models of cachexia [91,92].