In particular, evidence gathered about the effect of ectopic overexpression of NGB in the retinal tissue, and, in particular, in RGCs, converge to define a critical function of high induced levels of NGB in preserving retinal neuron loss and vision pathway under different stress conditions/retinal diseases as the main consequence of the globin ability to maintain or enhance mitochondrial functions, supporting the idea of NGB as the main target candidate for preserve or restore retinal tissue during degeneration [35,36,37,47,61,67]. The gene discussed is NGB; the disease is Abnormal retinal morphology.