In the n-HOFs, the mRNA expression of all four ECMs, except COL1 (Figure 3) or IL6 (Figure 4), were down-regulated or up-regulated, respectively, in the presence of OMD, while, in contrast, the significant down-regulation of COL1 and FN, and up-regulation of IL1β and IL6, were observed in the GHOFs. The gene discussed is FN1; the disease is occult macular dystrophy.