Therefore, in the current study, to elucidate the effects of OMD or Rip on n-HOFs and TSH, as well as IGF-1 receptor-activated n-HOFs, n-HOFs were obtained from patients with orbital fat herniations without GO and cultured in the form of 3D drop cultures [10,12] in the presence or absence of a recombinant human TSH receptor antibody, M22 and IGF-1 [13,14,15]. This evidence concerns the gene TSHR and occult macular dystrophy.