NOS2 and neoplasm: Therefore, strategic mechanisms to induce iNOS-derived NO and ROS in TAMs may directly destroy tumor cells in glioblastoma, which could also include cytotoxicity through stimulating Th1 responses by the production of CXCL9 and CXCL10 and by generating cytotoxic CD8 cells via IL1β and TNFα [90,94].