In a study that included blood samples from 13 hereditary TTR mutation patients (ATTRm), 11 senile cardiac amyloidosis patients (wild type TTR; ATTRwt), as well as healthy controls and heart failure patients, Derda et al. identified a significant upregulation of miR-339-3p in ATTRwt patients compared to the other cohorts [11]. Here, TTR is linked to cardiac amyloidosis.