Twenty-two genes, including SIN3A, BID, HGF, EPOR, CAMK2B, CREB5, PTPN11, NKD1, HNF1A, EFNA2, SMC3, SFRP1, PKMYT1, C19orf40, DDIT3, SOS1, DKK4, PRKAR1B, TNFRSF10A, LAMA1, ITGA2 and PGF were found in the 30 downregulated (in tumor MF) gene list. The gene discussed is SMC3; the disease is mycosis fungoides.