Roccaro et al. [74] demonstrated that MSCs-EVs contain oncogenic proteins, cytokines and adhesion molecules, including IL-6, MCP-1, junction plakoglobin, fibronectin, and express low level of the tumor-suppressive miR-15a compared to EVs derived from healthy MSCs, which promote tumor growth and dissemination of MM cells in vivo [74]. This evidence concerns the gene JUP and neoplasm.