Specifically, MM cells co-cultured with MM FBs-EVs selectively overexpress miR-214-3p and miR-5100, which trigger MM cells proliferation and resistance to bortezomib-induced apoptosis via activation of intracellular pathways involved in cell apoptosis and proliferation, i.e., MAPK, AKT/mTOR, p53 (unpublished data). This evidence concerns the gene TP53 and Miyoshi myopathy.