Seven-day-old neonatal ICR mice were pretreated with the CCR2 antagonist BMS (10 mg/kg) before infection with DENV2 PL046 (1 × 106) and then received an extra dosage of BMS at 2 days post-infection (dpi) and 5 dpi (Supplementary Figure S2A). This evidence concerns the gene CCR2 and infection.