Recently, two new synthetic AHR, ligands structurally related to the natural agonists FICZ, NPD-0614-13, and NPD-0614-24, were assessed on two different three-dimensional models of psoriasis—a reconstructed human epidermal equivalent and a full-thickness reconstructed skin—which represents a more complex system, due to the presence of psoriatic fibroblasts [171]. The gene discussed is AHR; the disease is psoriasis.