DPYSL2 and Huntington disease: In the present study, we assessed CRMP2 phosphorylation in postmortem brain tissues from HD patients and unaffected individuals, in cultured human striatal neurons derived from induced pluripotent stem cells (iPSCs) from HD patients and unaffected individuals, as well as in cultured striatal neurons from the transgenic HD mouse model YAC128 and their wild-type littermates.