Thus, CRMP2 expression and the phosphorylation pattern of CRMP2 at Thr 509/514 and Ser 522 in neurons from YAC128 mice was similar to the expression and phosphorylation profile of CRMP2 in postmortem brain tissues from HD patients (Figure 1) and in human striatal neurons derived from iPSCs of HD patients (Figure 2). Here, DPYSL2 is linked to Huntington disease.