Consistent with the results obtained from postmortem brain tissues, total CRMP2 expression was unchanged (Figure 2G,K), whereas CRMP2 was hyperphosphorylated at Thr 509/514 and Ser 522 in human striatal neurons from HD patients compared to neurons from unaffected individuals (Figure 2G,H,I). This evidence concerns the gene DPYSL2 and Huntington disease.