Similarly, (S)-LCM decreased Ser 522 and Thr 509/514 phosphorylation in human neurons from HD patients (Figure 2G,H,I) but did not affect the total CRMP2 and total Drp1 expression as well as Drp1 phosphorylation at Ser 616 (Figure 2G,J,K,L). This evidence concerns the gene CRMP1 and Huntington disease.