IL1B and arthritic joint disease: Our findings in relation to PL in EIU are in agreement with other investigations that showed the anti-inflammatory potential of PL, such as in the reduction of ear edema induced by croton oil [54], analgesia and suppression of the stress response caused by pain in a dose-dependent manner [55], and decreased release of TNF-α and IL-1β in collagen-induced arthritis [56].