In the model of allergic conjunctivitis, low levels of IL-10 were also observed after treatment with Ac2-26, and a significant increase in this cytokine occurred in AnxA1-null animals [32], indicating the importance of Th1/Th2 balance in the development of allergic inflammatory responses and suggesting that the protective role of AnxA1 in ocular allergy occurs through downregulation of both cytokine profiles. The gene discussed is IL10; the disease is atopic conjunctivitis.