Except for one study (n = 171) [12], large cohorts showed that PD-L1 expression was higher in the advanced pT tumor stages (Xian et al., n = 279; Calagua et al., n = 351) [43,75]; conversely, smaller series (Obradovic et al.: 29 cases [29]; Wagle et al.: 21 cases [28]) did not find any correlation. Here, CD274 is linked to neoplasm.