The lncRNA PCED1B-AS1, associated with exosomes derived from hepatocellular carcinomas, was shown to enhance PD-L1 expression in cancer cells while inhibiting T cell and macrophage function [66], while lncRNA SNHG16, associated with breast cancer-derived exosomes induces immunosuppressive CD73+ γδ1 Treg cells [67]. The gene discussed is CD274; the disease is cancer.