In details, chemotherapy-naïve animals bearing either the LLC or the C26 tumor present with no changes in PGC-1α levels [33], yet our observations presented here reveal that PGC-1α expression is significantly decreased in the skeletal muscle of C26-bearing mice only when a muscle injury has been inflicted (i.m. injection of BaCl2; Figure 3A,B, see Appendix A for methodological details). Here, PPARGC1A is linked to neoplasm.