p53, as a tumor suppressor, transcriptionally regulates a lot of target genes that are implicated in various biological processes including DNA damage repair (i.e., GADD45α, PCNA), cell cycle arrest (i.e., CDKN1A), senescence, and apoptosis (i.e., Puma, Noxa, Bax, Bid, Casp1, 6 and 10) [18]. This evidence concerns the gene PMAIP1 and neoplasm.