Pathologically, AD is characterised by the presence of extracellular amyloid-beta (Aβ) protein aggregates, named plaques, as well as intracellular neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein, in central nervous system (CNS) tissue, and widespread CNS neuronal cell death and brain tissue atrophy [4,5]. Here, MAPT is linked to Alzheimer disease.