ACE and Hypertension: Rossi et al. in a transgenic model of severe hypertension and cardiovascular damage, the TG(mRen2)27 rat, created by the insertion of the mouse renin gene into the rat genome, found that either angiotensin-converting enzyme (ACE)-inhibition with ramipril [66], or the block of AT1R with AT1 receptor blocker irbesartan [67] prevented TIF, supporting the fibrogenic role of angiotensin II.