Knockdown of DJ-1 in M17 human dopaminergic neuroblastoma cells resulted in oxidative stress and compromised mitochondrial dynamics together with an increase in LC3-II levels, thus suggesting that DJ-1 might play a role in the modulation of autophagy in response to the presence of reactive oxygen species (ROS) [125]. The gene discussed is PARK7; the disease is dopaminergic neuroblastoma.