LRRK2 and Parkinson disease: This is true, for example, in the presence of mutations affecting proteins such as leucine-rich repeat kinase 2 (LRRK2), ubiquitin C-terminal hydrolase L1 (UCHL1), and DJ-1 (PARK7), all of which are responsible for the onset of familial forms of PD and can be degraded by CMA [59,66,67,68].