Finally, peripheral blood mononuclear cells (PBMCs) isolated from PD patients can also be used to detect the presence of biomarkers, exhibiting diminished levels of HSC70 and Lamp-2A along with an up-regulation of LC3, ULK1, Beclin-1, and AMBRA1 [76,77,78,79]. The gene discussed is AMBRA1; the disease is Parkinson disease.