Functional studies in cancer cell lines and murine tumour models have demonstrated that the loss of the Hippo pathway components and the overexpression (or hyperactivation) of oncogenic YAP/TAZ closely correlates with the hallmarks of cancers; some of these hallmarks include hyperproliferation, metastasis, cancer stem cell maintenance, therapeutic resistance and even regulation of T cell-mediated anti-tumour responses [35,50,51]. This evidence concerns the gene WWTR1 and neoplasm.