Interestingly, all datasets displayed an enrichment of polycomb group protein-associated signatures (i.e., EZH2, BMI1, and MEL18) and the majority (CML, CRC, LC, and HCC) showed an enrichment in Ribosomal Protein S14 (RPS14)- and Retinoblastoma (RB)-related pathways. The gene discussed is RB1; the disease is laryngotracheoesophageal cleft.