PRKN and Parkinson disease: Other mechanisms involving CHIP-chaperone interactions include inherited forms of PD: CHIP-HSP90-dependent degradation of leucine-rich repeat kinase-2 (LRRK2) [92,93], CHIP-HSP70-dependent enhancement of the E3 activity of Parkin (PRKN) [94], and CHIP-HSP70 dependent degradation of PTEN-induced putative kinase 1 (PINK1) [95].