Given the ability of HOP to facilitate protein folding by coordinating with HSP70 and HSP90, increased expression of HOP in the backdrop of cancer creates a pro-folding environment facilitating the folding and accumulation of oncogenic proteins, such as HER2, Bcr-Abl, c-MET, and v-Src (Figure 5) [218,219,220]. The gene discussed is STIP1; the disease is cancer.