BAG3 and familial dilated cardiomyopathy: In healthy human iPSC-derived cardiomyocytes edited with the CRISPR-Cas9 system, a heterozygous knock-in DCM-associated mutation, BAG3-R477H, and a BAG3 knockout decreased BAG3/HSP70 complex formation and resulted in myofibrillar disarray under proteasome inhibition [169].