The importance of KISS1 in reproduction cannot be understated as whole-body knockouts of KISS1 or its receptor, GPR54/KISS1r, lead to hypogonadotropic hypogonadism, a condition where little to no sex hormones are produced, resulting in infertility and the loss of puberty [142,143]. This evidence concerns the gene KISS1R and hypogonadotropic hypogonadism.