miR-1983 levels were also increased in the hypothalamus of MKR mice [72], a non-obese model with impaired insulin signaling and hyperinsulinemia [73], and was positively correlated to insulin and homeostatic model for insulin resistance (HOMA-IR) scores in human serum samples, representing their potential for use as a biomarker. This evidence concerns the gene INS and Hyperinsulinemia.