APP and Alzheimer disease: As shown in Figure 6C, synaptic proteins, including synaptophysin (p = 0.0001) and PSD95 (p = 0.0139), were significantly reduced in Rlip+/− mice, a result that is similar to the mRNA and immunoblot results and similar to previously published immunofluorescence data on the APP and tau transgenic mouse models of AD [66,67].