TNFAIP6 and Alzheimer disease: Of interest, as HA is particularly retained in intercellular spaces by TSG-6 protein [65] (Figure 3), and TSG-6 protein is increasingly produced in vivo in AD skin, such as in vitro in reconstructed epidermis challenged with Th2 cytokines, this anti-inflammatory protein might favor the accumulation of HA in pathologies, such as AD [65].