Coumarin and its derivatives demonstrate their potential in treating AD through several mechanisms such as inhibiting AChE [50] and β-secretase [51], preventing misfolded Aβ aggregation [21], upregulating CREB and anti-oxidative pathways [22,23], and promoting BDNF-TRKB and CREB signaling [24,25]. Here, CREB1 is linked to Alzheimer disease.