CXCR2 and cancer: CXCL5 signaling through the cognate receptor CXCR2 induces pro-inflammatory changes in the TME of different cancer types and augments cancer metastases through upregulating EMT pathways such as extracellular signaling-regulated kinase 1/2 (ERK1/2), glycogen synthase kinase 3 beta (GSK3 β), and SNAIL family transcriptional repressor 1 (Snail) [15,18].