MMP21 and cholangiocarcinoma: Treatment of HuCC-T1 with LEC-CM and LPS-LEC-CM for 24 h significantly induced MMP1 and MMP21 in LPS LEC CM treated HuCC-T1, two critical MMP genes (p ≤ 0.001) (Figure 1F) thus highlighting a potential role of inflamed LECs in matrix remodeling in CCA that could potentially promote metastasis.